NEWS Release
International Wex Technologies'
Tectin™ Study Results Show Efficacy in Pain Management
Phase
IIa final results announced at International Scientific Meeting
Date: May 7, 2004
Toronto Stock Exchange
Trading Symbol: WXI
http://www.wextech.ca
E-mail: wex@wextech.ca
International Wex Technologies
(TSX: WXI) today released the final results of its Phase IIa study
of tetrodotoxin (Tectin™), an investigational treatment for
the management of severe cancer-related pain, at the 2ndJoint Scientific
Meeting of the American Pain Society and the Canadian Pain Society
being held in Vancouver, BC May 6 - 9, 2004.
The Phase IIa results demonstrate
that Tectin™, administered intramuscularly for four days at
the studied doses, is well tolerated and can relieve refractory
cancer pain for up to two weeks in some patients. Consistent with
the interim analysis, the final results show that almost three-quarters
(72 per cent) of cancer pain patients experienced a clinically meaningful
analgesic response.
The study was conducted in
seven centers involving six Canadian cities: Saskatoon, Edmonton,
Calgary, London, Montreal, and Toronto.
"We are definitely encouraged
by the Phase IIa results," said Dr. Neil Hagen, Lead Investigator
of the study. "In light of the safety profile of tetrodotoxin within
this study, and the unsatisfactory pain management options available
for patients with refractory cancer pain, further study of tetrodotoxin
in a large multicenter controlled trial is warranted. We believe
that the current Phase IIb/III study will be one of the largest
and most important Canadian clinical trials conducted to date to
evaluate the efficacy and safety of a drug for medically refractory
cancer pain."
This pivotal trial of Tectin™
is a randomized, double-blind and placebo-controlled study comparing
the efficacy and safety of Tectin™ versus placebo in patients
with moderate to severe inadequately controlled cancer pain. The
trial is currently ongoing in up to 25 treatment centers across
Canada with a target completion in the next 12 months. There is
an Interim analysis expected once 50% of the patients have completed
the study.
The study is being led by
two nationally respected leaders in cancer pain assessment and management,
Dr. Neil Hagen, Head of the Division of Palliative Medicine, Department
of Oncology at the University of Calgary and Dr. Bernard Lapointe,
Chief of the Palliative Care Division of the Jewish General Hospital
in Montreal, and Associate Professor in the Department of Oncology
and the Department of Family Medicine at McGill University.
"We are pleased with the
promising results from the Tectin™ trials thus far and this
reinforces the corporate direction to continue our research in this
area." said Donna Shum , Chief Operating Officer of International
Wex Technologies Inc. "We believe the work with blowfish toxins
will contribute to the benefit of improving the quality of life
to patients whose pain is not adequately controlled by currently
available therapies."
Tectin™, which is
derived from the puffer fish - also known as blow fish or Fugu -
was developed to block slow sodium channel nociceptive pain fibers
in a highly selective manner. The product exhibits potent analgesic
properties in animal studies and is currently under clinical investigation
in pain management.
International Wex Technologies
Inc., a publicly listed neuro-bioscience company (WXI), is focused
on the development and commercialization of innovative drug products,
primarily for pain management. The Company's lead compound, Tetrodotoxin,
is a sodium channel blocker and is the platform for the Company's
development of a portfolio of proprietary products in the field
of analgesia, drug addiction withdrawal treatment, and local anaesthesia.
For additional information
on our products visit us at http://www.wextech.ca or call Don Evans
or Gordon Stanley, Corporate Communications at 604-683-8880, or
at 1-800-722-7549.
Per: Donna Shum, Corporate
Secretary
The Toronto Stock
Exchange has not reviewed and does not accept responsibility for
the adequacy or accuracy of the content of this News Release.
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